Objective 1: Synthesis of a library of lactose-derived chiral N,N and N,N,N chiral ligands to investigate their ability to induce levels of enantioselectivity in metal-catalysed asymmetric transformations.

Deliverables:

Synthesis of gram quantities of lactose-derived N,N ligands with a range of alcohol-protected groups.
Synthesis of gram quantities of lactose-derived N,N,N ligands with a range of alcohol-protected groups.
Prepare metal complexes of these ligands for structural characterisation (X-ray crystallography).
Objective 2: Applications in asymmetric catalysis – screen a range of metal-catalysed processes to test the enantiodifferentiating ability of these novel ligands.

Deliverables:

Testing metal complexes of lactose-derived N,N ligands in asymmetric catalysis.
Testing metal complexes of lactose-derived N,N,N ligands in asymmetric catalysis.
Optimisation of successful asymmetric catalytic transformations to include a substrate scope.